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Title   인체의 신경아세포종 세포주에서 분화 유도에 따른 세포 접합 물지르이 발현 및 세포유전학적 변화에 관한 연구 ( Changes of Intercellular Adhesion Molecule Expression and Cytogenetic Abnormalities during the Differentiation Process in Human Neuroblastoma Cell Lines )
Publicationinfo   1993 Jan; 025(04): 563-572.
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Abstract   Neuroblastoma is one of the most common solid neo#Dlasm in childhood, which still has relatively poor prognosis despite advanced therapeutic modalities. It is characterired by the poten- tial to differentiate into more mature, ganglion cell-like phenotype in the presence of certain agents such as y-interferon and retinoic acid, and there have been some reports as to the chang- es of the cell surface adhesion molecule expres#sion during the differentiation of neuroblastoma cells, induced by these agents. The cell surface adhesion molecules seem to be potential adjuncts in the treatment of tumors by immune modulators such as NK or LAK, and we performed a chronological observa- tion of the changes of various cell surface adhesion molecule(NCAM, ICAM, LFA-1, LFA-3, HLA-ABC, HLA-DR) expression in three neuroblastoma cell lines(IMR-32, SK-N-MC, SK-N- SH) having different characteristics during the differentistion induced by y-interferon and retinoic acid, along with chromosomal findings and N-myc expression. There was no chrono- logical changes of cytogenetic features in all cell lines during differentiation process and N- myc amplification was present in IMR-32 only. The expression of surface adhesion molecules ICAM and HLA-ABC increased as the cells differentiate into more mature phenotype in all cell lines under the influence of r-interferon or retinoic acid. The general patterns of cell surface adhesion molecules had minor differences. Above results implicate that the r-interferon and retinoic acid, by inducing changes of cell surface adhesion molecule expression, may be potential adjuncts in the immunotherapy of neuroblastoma using NK or LAK cells. Key Words: Neuroblastoma, Cell surface adhesion molecule, r-interferon, Retinoic acid
저 자   김종재(Chong Jai Kim),최윤정(Yoon Jeong Choe),김철우(Chul Woo Kim)